---
title: "US EO 14110 — Safe, Secure & Trustworthy AI (biosecurity / dual-use provisions) — KYE Protocol™ coverage"
description: "US EO 14110 — Safe, Secure & Trustworthy AI (biosecurity / dual-use provisions) coverage by KYE Protocol™ — every requirement bijection-mapped to the KYE™ artefact that enforces it."
url: https://kyeprotocol.com/compliance/us-eo-14110/
lang: en
source: "KYE Protocol"
---

> US EO 14110 — Safe, Secure & Trustworthy AI (biosecurity / dual-use provisions) coverage by KYE Protocol™ — every requirement bijection-mapped to the KYE™ artefact that enforces it.

US EO 14110 — Safe, Secure & Trustworthy AI (biosecurity / dual-use provisions)

# US EO 14110 — Safe, Secure & Trustworthy AI (biosecurity / dual-use provisions) — 50% of in-scope requirements covered.

4 requirements · 4 in scope (4 designed). The 50% is weighted over the in-scope base.

**Source:** US Executive Order 14110 (30 Oct 2023), 'Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence' — established federal expectations around dual-use biology, nucleic-acid synthesis screening as a condition of federal funding, and content provenance / authentication. KYE Protocol™ governs whether an AI-generated sequence/molecule/protocol may PROCEED to a consequential action (synthesis, wet-lab, regulated stage), screened against dual-use controls, with replay-provable provenance — the obligations EO 14110 established for the bio/chem AI layer. KYE™ does not fold proteins, design molecules, or judge scientific validity. · **License:** US federal Executive Order text is in the public domain; KYE™ registry cites the order and its biosecurity / synthesis-screening / provenance provisions for mapping purposes.

## By category

| Category | Reqs | Enforced | Designed | Advisory | Deferred | Coverage |
| --- | --- | --- | --- | --- | --- | --- |
| Dual-use biology & synthesis screening | 2 | 0 | 2 | 0 | 0 | **50%** |
| Content provenance & authentication | 1 | 0 | 1 | 0 | 0 | **50%** |
| Human oversight of consequential AI action | 1 | 0 | 1 | 0 | 0 | **50%** |

## Every requirement → the KYE™ artefact that enforces it

| ID | Title | Status | KYE™ enforcement |
| --- | --- | --- | --- |
| `us-eo-14110.4.4-synthesis-screening` | Nucleic-acid synthesis screening as a condition of consequential synthesis | designed | **rule\_packs**: `kye:rule-pack:bio-chem-governance` **dictionaries**: `internal` **constitution\_refs**: `constitution/25-EDGE-GOVERNANCE.md` |
| `us-eo-14110.4.4-dual-use-bio` | Dual-use biological design screened before a consequential action | designed | **rule\_packs**: `kye:rule-pack:bio-chem-governance` **dictionaries**: `internal` **constitution\_refs**: `constitution/12-PURPOSE-PERMISSION.md` |
| `us-eo-14110.4.5-provenance` | Content provenance & authentication for AI-derived artefacts | designed | **rule\_packs**: `kye:rule-pack:bio-chem-governance` **dictionaries**: `internal` **constitution\_refs**: `constitution/13-RESILIENCE-LOOP.md` |
| `us-eo-14110.human-oversight` | Human oversight of consequential AI-driven bio/chem action | designed | **rule\_packs**: `kye:rule-pack:bio-chem-governance` **constitution\_refs**: `constitution/36-GOVERNEDUI.md` |

Canonical KYE™ surfaces referenced on this page: [KYE Protocol™](https://kyeprotocol.com/).