Nucleic-Acid Synthesis Screening — IBBIS Common Mechanism + IGSC Harmonized Screening Protocol
Nucleic-Acid Synthesis Screening — IBBIS Common Mechanism + IGSC Harmonized Screening Protocol — 50% of in-scope requirements covered.
4 requirements · 4 in scope (4 designed). The 50% is weighted over the in-scope base.
Source: The biosecurity screening regime for synthetic nucleic acids — the International Biosecurity and Biosafety Initiative for Science (IBBIS) Common Mechanism and the International Gene Synthesis Consortium (IGSC) Harmonized Screening Protocol. These screen synthesis orders for sequences of concern (regulated pathogens, toxins, controlled genetic elements) and the customers placing them BEFORE synthesis proceeds. KYE Protocol™ governs whether an AI-generated nucleic-acid sequence may PROCEED to a synthesis order, binding the sequence-of-concern screening result and proving it was checked. KYE™ does not run the BLAST/HMM screening pipeline or judge whether a sequence is genuinely of concern. · License: IBBIS Common Mechanism and IGSC Harmonized Screening Protocol are published reference protocols; KYE™ registry cites their screening obligations for mapping purposes and reproduces no protocol text.
By category
| Category | Reqs | Enforced | Designed | Advisory | Deferred | Coverage |
|---|---|---|---|---|---|---|
| Sequence-of-concern screening | 2 | 0 | 2 | 0 | 0 | 50% |
| Customer / legitimacy screening | 1 | 0 | 1 | 0 | 0 | 50% |
| Screening provenance & record-keeping | 1 | 0 | 1 | 0 | 0 | 50% |
Every requirement → the KYE™ artefact that enforces it
| ID | Title | Status | KYE™ enforcement |
|---|---|---|---|
nucleic-acid-synthesis-screening.soc-screen | Sequence-of-concern screen recorded before synthesis proceeds | designed | rule_packs: kye:rule-pack:bio-chem-governancedictionaries: internalconstitution_refs: constitution/25-EDGE-GOVERNANCE.md |
nucleic-acid-synthesis-screening.flagged-hold | Flagged sequence held pending review — not auto-proceeded | designed | rule_packs: kye:rule-pack:bio-chem-governanceconstitution_refs: constitution/36-GOVERNEDUI.md |
nucleic-acid-synthesis-screening.customer-screen | Customer / order-legitimacy screening recorded | designed | rule_packs: kye:rule-pack:bio-chem-governanceconstitution_refs: constitution/12-PURPOSE-PERMISSION.md |
nucleic-acid-synthesis-screening.screening-provenance | Screening result retained as replay-provable provenance | designed | rule_packs: kye:rule-pack:bio-chem-governancedictionaries: internalconstitution_refs: constitution/13-RESILIENCE-LOOP.md |
Canonical KYE™ surfaces referenced on this page: KYE Protocol™.